MULTISYSTEMIC MANIFESTATIONS IN A COHORT OF 75 CLASSICAL EHLERS-DANLOS SYNDROME PATIENTS: NATURAL HISTORY AND NOSOLOGICAL PERSPECTIVES

Multisystemic manifestations in a cohort of 75 classical Ehlers-Danlos syndrome patients: natural history and nosological perspectives

Abstract Background The Ehlers-Danlos syndromes (EDS) are rare connective tissue disorders consisting of 13 subtypes with overlapping features including joint hypermobility, skin and generalized connective tissue fragility.Classical EDS (cEDS) is principally caused by heterozygous COL5A1 or COL5A2 variants and rarely by the COL1A1 p.(Arg312Cys) sub

read more


An interdisciplinary approach to Iron Age Mediterranean chronology through combined archaeological and 14C-radiometric evidence from Sidon, Lebanon.

The construction of the Iron Age Mediterranean chronology began in the Levant based on historical evidence and has been additionally supported in recent decades by means of radiocarbon analysis, although with variable precision and ratification.It is only in recent years that new evidence in the Aegean and the western Mediterranean has opened discu

read more